AKAP150-mediated TRPV1 sensitization is disrupted by calcium/calmodulin
Abstract Background The transient receptor potential vanilloid type1 (TRPV1) is expressed in nociceptive sensory neurons and is sensitive to phosphorylation.A-Kinase Anchoring Protein 79/150 (AKAP150) mediates phosphorylation of TRPV1 by Protein Kinases A and C, modulating channel activity.However, few studies have focused on the regulatory mechani